Genes and Alzheimer’s
Dear Caregivers,
Despite many scientific advances in what we know about Alzheimer's disease and how it damages the brain, the reasons why some people develop it, while others are spared, is less clear. The observation that higher rates of developing Alzheimer's disease occurs in certain ethnicities and within some families has led to an understanding about the impact of genetic factors. Now a recent study is adding to our knowledge about how specific genes contribute to the risk of developing Alzheimer's disease.
The study, published in a highly-respected scientific journal, found that in a large survey of subjects who carried two copies of a particular variant of a gene, known as APOE4, nearly 100% of them developed Alzheimer’s disease. In addition, their symptoms appeared earlier in their lives, some as young as in their early 50s. It’s not quite clear how this finding can be extended globally, as most of the subjects in this study were of European descent, so it remains to be seen whether the results can be duplicated in other populations.
Reporting on these kinds of scientific developments is, for me, an important responsibility. I take seriously my role as a physician to translate what is learned from science into information we can all understand and benefit from. The new research on the involvement of genes in Alzheimer's is part of science’s ongoing effort to identify better ways to diagnose and treat the disease. And while these discoveries may not directly benefit you or your loved ones at the moment, I know you share with me the hope that this progress continues in earnest, step by step, adding to our understanding of the causes of Alzheimer’s, and ultimately resulting in finding a cure, so that no one need face this illness.
Here is some more guidance about the causes and treatments of Alzheimer’s:
Is Alzheimer’s Hereditary?:
A so-called “family history” is not always associated with developing the disease — it is likely a combination of genetic, other medical, and lifestyle risk factors. Here’s an overview.
Testing for Alzheimer’s Genes:
There is scientific evidence that in some cases, genes can play a role in the development of Alzheimer’s disease. The most common gene that increases the risk of Alzheimer’s is known as “APOE”. Here’s a list of commercial companies that test for the presence of the gene.
Should We Try the Medications for Alzheimer’s Disease?:
With any new medication, it is critical to think about the potential benefits as well as the possible side effects. Since there is currently no drug that will cure the illness, the last thing we want to do is reduce the patient’s quality of life with side effects. Here’s what you need to know.
Remember, if you can’t find the information you need on our website, you can always “Ask NAN” by clicking on this link.
Best,
Rosemary D Laird, MD, MHSA
Founder and Chief Medical Officer
“The man who moves a mountain begins by carrying away small stones.”
— Confucius
